To make matters worse, the presumed benefits soon began to look illusory.
And the presumed benefit of taking the drug was to prevent heart disease.
These other presumed benefits have sometimes been critical in women's decisions on whether to undergo hormone replacement therapy, and for how long.
But the panel concluded that many other presumed benefits did not hold up when examined in rigorous clinical trials.
There is scant evidence to support the presumed benefits, and now there is a signal of potential harm.
They complain that many of the presumed benefits of the new digital world would be lost under such a system.
But many economists, politicians and union officials are skeptical about the presumed benefits of selling the water industry.
Less than three months ago an international panel concluded that there was little evidence to support many of the presumed benefits of the treatments.
The presumed benefits would be improved quality and higher standards of health care.
Most of the data on the presumed benefits of hormone replacement come from observational studies of women who chose to take it or not.