Depression as an evolutionary adaptation: Implications for the development of preclinical models.

Rapalogs, which are the first generation mTOR inhibitors, have proven effective in a range of preclinical models.

However, the present data in a well-established preclinical model of breast cancer, employing a variety of highly effective chemopreventive regimens, suggest that this is not the case.

This issue could be reassessed in preclinical models using the same agents to treat established proliferative intraepithelial neoplasia.

Clostridial vectors can be safely administered and their potential to deliver therapeutic proteins has been demonstrated in a variety of preclinical models.

As a result, they are good preclinical models for understanding processes like immortalization and its role in promoting cancerous tumors.

Jerini's compound (JSM 6427) has shown significant efficacy in combating disease progression in preclinical models.

This use of Clostridium has been demonstrated in a variety of preclinical models.

Administration of specific nutrients was also shown to improve learning and memory in preclinical models.

The success of cancer immunoprevention in preclinical models suggests that it might have an impact also in humans.