It is lucky that most plant toxins are bitter or unpleasant to taste or smell.
Some animals have digestive systems especially adapted to cope with certain plant toxins.
Butterflies have evolved mechanisms to sequester these plant toxins and use them instead in their own defense.
In treating exposure to the plant toxin, timing is everything, specialists in poison ivy have discovered.
However, the safety of internal use needs further research due to the presence of plant toxins.
The plant toxin renders both the caterpillar and the adult butterfly particularly repellent to natural enemies.
In addition, some tribes are known to have used plant toxins to induce torpor in stream fish to enable their capture.
The same might be true of plant toxins as well; they had evolved to affect other life, not humans.
Nevertheless, some plant toxins have become "popular" as self-harm agents, used in suicides.
They are able to neutralize plant toxins produced by Ligustrum.