After another thousand years, pioneers again crossed the mountains and entered Africa.

In September 1662, after the deed was signed with a Native American chief, "Great John", the pioneers entered this part of what is now southern Worcester County.

The Mormon settlement of Utah began in July 1847, when pioneers entered the Salt Lake Valley.

These show the pioneers entering the valley and an irrigation scene.

The town was first settled around 1773, but most pioneers did not enter the area until after the Revolutionary War.

But when the pioneers entered Salt Lake Valley in 1847, they only saw the range's dark green forest and ruddy soil.

On the left side of the cornice ledge, Native Americans are forced west, while Euro-American pioneers enter from the east.

Such laboratory deaths are extremely rare, researchers and Federal safety officials say, but scientific pioneers often enter regions without safety nets.

Early pioneers like Robert William Paul or James Williamson entered on their new enterprise with confidence, even though they were only individual craftsmen working out of small workshops and studios.

But other pioneers in the field have entered the commercial arena, either as advisers to existing companies or as biotech entrepreneurs.