Over 99% of insulinomas originate in the pancreas, with rare cases from ectopic pancreatic tissue.

In some cases pancreatic tissue is permanently damaged or even dies (necrosis).

If much of your pancreatic tissue has died, you may become malnourished because the pancreas no longer produces enzymes needed to digest fat and protein.

In the most severe cases, surgery is needed to remove dead or infected pancreatic tissue.

In July 1916, Pybus reported an attempt at allogenic transplantation of pancreatic tissue.

In pancreatic acinar tissue, these subunits were found in zymogen granules.

About 100 mg pancreatic tissue was excised and frozen at -20 C until assay performed two to four days afterwards.

They can also be found in developing embryonic pancreatic tissue.

Another example is a Meckel's diverticulum which may contain heterotopic gastric or pancreatic tissue.

British researchers have found a way to turn embryonic stem cells into insulin-producing pancreatic tissue.