Tell your doctor immediately if any of these rare but very serious side effects occur: symptoms of possible lymphoma (such as swollen or painful abdomen, persistent fever, night sweats, unexplained weight loss), change in amount of urine, pain in the lower back/side.

Another aspect of the painfulness of EPP is the painful abdomen, which may manifest as generalized pain, or may imitate an appendicitis.

A swollen, painful abdomen.

Tell your doctor right away if you develop symptoms such as unusual lumps/growths, swollen or painful abdomen, unexplained weight loss, persistent fever or night sweats.

Guarding is a characteristic finding in the physical examination for an abruptly painful abdomen (an acute abdomen) with inflammation of the inner abdominal (peritoneal) surface due, for example, to appendicitis or diverticulitis.