If that were the only risk, I would wonder about the overall usefulness of the vaccine," DiCarlo said.

The small coverage also reduces the overall usefulness of the network, as many of the lanes do not connect with each other (see Metcalfe's Law).

US Steel justified the sale on the grounds that Isthmian's overall usefulness had diminished, as it now carried only a fraction of the Corporation's exports.

Its overall usefulness, however, has been limited by natural features, including a number of cataracts in the main Nile between Khartoum and the Egyptian border.

Obviously, this factor alone governs a guitar synth's overall usefulness as a serious music tool, and I'm happy to report a significant improvement here.

This, however, does not impede the overall usefulness of the technology.

It enables the effective comparing and sharing of architecture data across the enterprise, contributing to the overall usefulness of architectures.

So, due to its very northern location, and mere spur-like connection to the B&O, its overall potential usefulness to the Confederacy was not great.

However, dose-limiting toxicities may limit the overall usefulness of thalidomide.

As regards overall usefulness and validity, each person must make up their own mind.