The optimal duration of treatment for patients with disseminated infections is not clear.

The optimal duration of adjuvant therapy is currently unknown; trials are ongoing evaluating treatment durations of 1, 2, and 3 years.

The optimal duration of adjuvant trastuzumab is currently unknown.

The optimal duration of treatment for highly resistant strains has not been established.

The issue of optimal duration of letrozole therapy is important, but our study was not designed to answer this question, which must be resolved in future trials.

The optimal duration of therapy and the issue of utility of neoadjuvant hormonal therapy have not been determined.

Another area of research will be the optimal duration of treatment with tamoxifen and whether it needs to be lifelong.

The optimal duration of PEP is unknown.

"The next step is to do an extended trial to find out the optimal duration of treatment and long-term side effects."

Sleep itself assumes a profundity in his treatment - beyond the content of its dreams or the optimal duration of its nightly reign.