In the Senatorial election of 2008, she was the Republican nominee, losing to the incumbent, Joe Biden, by 65% to 35%.

In 1974 Kennedy was the unsuccessful Republican nominee for Governor, losing to incumbent Thomas P. Salmon.

In 2002, he was the Democratic nominee for Attorney General, losing to Republican Phill Kline by less than 1%.

He became the Republican nominee for president in 1856, losing to James Buchanan.

In 2001, he was the Democratic nominee for mayor, losing narrowly to the Republican candidate, Michael R. Bloomberg.

In 1994, Smith was the Republican nominee for Oregon governor, losing to Democrat John Kitzhaber.

Four years later he was the Democratic nominee for Wyandotte County, losing in a close election.

He was the 2010 Democratic nominee for Governor of South Carolina, losing in a narrow election.

In 1966 Anderson was the unsuccessful Republican nominee for Auditor, losing to Gordon.

He was again the Democratic nominee in 1952, losing to Howard Alexander Smith.