The 1990s saw the most significant changes to the school since the 1960s.

The most significant thing was to win the game and to make sure we would be playing next week.

Their works are usually thought of as the most significant in the form.

They did at least have a hand in the most significant deal of the day.

All our most significant social and political problems go back at least 300 years.

Those changes are the most significant under the new law.

And then came the most significant turn in the election.

But some of the most significant effects may be political.

But he would certainly be the one to play the most significant role in doing it.

"These are by no means the most significant of the lot?"