When they should have been at their weakest, they became most malignant.

His face was regular in outline, and would have been handsome, were it not for the distortion due to a most malignant expression.

You are a most malignant and dangerous Whig to have so far drawn them from their duty.

The final and most malignant scowl is for Jack, who raises his eyebrows.

They are the most malignant type of canine mammary tumor.

Grade one is least harmful and grade four is most malignant.

He had the most malignant manner I ever saw.

I turned and gave him my prettiest, most malignant smile.

While still in the cradle he had been attacked by smallpox of the most malignant type.

Ovarian cancer is the most malignant tumour of the female reproductive organs.