After mitotic arrest at 48h with colchicine, the percentage of cells with dicentric chromosomes was determined (Fig. 1).

Further evidence also suggests that survivin is needed for sustaining mitotic arrest upon encounter with mitosis problems.

The evidence mentioned above implicates that survivin plays an important regulatory role both in the progression of mitosis and sustaining mitotic arrest.

Eukaryotic cells show a mitotic arrest in the presence of microtubule polymerization inhibitors.

Multinucleation is usually accomplished through causing prolonged mitotic arrest by colcemid treatment.

MAD2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein.

Treatment with antiP2 antibodies causes mitotic arrest at the first nuclear division and disruption of the tubovesicular network which is set up during the trophozoite stages.

The SAC was found to be the key signaling pathway to the mitotic arrest.

Permanent activation of the SAC ensues along with a mitotic arrest that lasts several hours.

Likewise, inhibition of PLK1 facilitates mitotic arrests and cell apoptosis.