Therefore, it was possible to use lower doses of cyclosporine which minimized toxicity of the drug.

Area-under-the-curve monitoring gives an estimate of total drug exposure and may help minimize toxicity, particularly in patients with unusual clinical responses to standard dosing [ 20 ] .

Lowering the dose of hydroxyurea minimizes toxicity and maximizes anti-HIV potency.

Other examples of drugs with a narrow therapeutic range, which may require drug monitoring both to achieve therapeutic levels and to minimize toxicity, include: dimercaprol, theophylline, warfarin and lithium carbonate.

In implementing these guidelines, health-care providers face the ongoing challenge of developing treatment strategies that minimize drug-related toxicity and adverse effects while retaining effective control of viral replication.

This low dose of cyclosporin was chosen to minimise toxicity since prolonged treatment (up to five years) was planned.

Cryobiologists attempt to optimize cryoprotectant concentration (minimizing both ice formation and toxicity) as well as cooling rate.

Vitrification methods pose a challenge in the requirement to search for cryoprotectant mixtures that can minimize toxicity.

Infusing foscarnet with saline fluid loading can minimize renal toxicity.

The first is maximizing yield and minimizing toxicity.