The mean frequency does not change, but the upper states move further apart, and so do the frequencies of the bands.

When listening to pitches with vibrato, there is evidence that humans perceive the mean frequency as the center of the pitch.

In Iberia the mean frequency of Haplogroup L lineages reaches 3.83% and the frequency is higher in Portugal (5.83%) than in Spain (2.90%) and without parallel in the rest of Europe.

Thus the mean frequency of aphasia for left handers was almost twice as great among left handers as right handers.

This haplogroup reaches a mean frequency of 42% in North Africa, decreasing in frequency from approximately 80% or more in some Moroccan Berber populations, including Saharawis, to approximately 10% to the east of this range in Egypt.

Two reports found no differences in the mean frequency of heartburn and regurgitation, and a higher prevalence of dysphagia in the Barrett's group compared with reflux oesophagitis patients.

When given sildenafil for 4 weeks subjects had reduced mean frequency and duration of Raynaud attacks and a significantly lowered mean Raynaud's condition score.

The mean frequency is calculated based on the autocorrelation with lag one, evaluated over a signal consisting of N samples:

The mean frequency can be expressed by the central wavelength, and the effective bandwidth by means of the coherence length, .

This haplogroup reaches a mean frequency of 42% in North Africa, decreasing in frequency from 100% in some isolated Berber populations to approximately 10% to the east of this range in Egypt.