He married, in 1778, Mary, daughter of the Rev. William Danby, and widow of Thomas Lockhart.

He married secondly in 1755, Ellen, daughter and heiress of John Thresher of Bradford on Avon.

He married in 1623 Anne, daughter of Sir William Meredith and widow of Sir Robert Brett.

He married in 1656 Sarah, daughter and co-heiress of Sir Edward Alston and widow of George Grimston.

He married at Tiverton in 1757 Margaret, second daughter and co-heiress of John Newton of that town.

He married in 1851, Anne, only daughter and heiress of Richard Thompson of Stansty Hall, Denbighshire.

He married, in 1554, Susan, daughter and heiress of Henry Webbe.

He married in 1909 Muriel, daughter of the late Russell Stephenson and widow of the Hon. Oliver Howard.

Sir Henry married, in April 1619, Anne, daughter and coheiress of William Holliday, alderman of London.

Crew married secondly in 1674, Anne, daughter and co-heiress of Sir William Airmine, 2nd Baronet.