There were two major outbreaks of yellow fever, in 1854 and 1867.

This was the first major outbreak of the 21st century, and is the second biggest in November.

What we can hope to do is prevent a major outbreak.

There has been no major outbreak of disease in Iraq.

They'd know they were faced with a major outbreak of technology.

It is the first major outbreak for many years.

There was another major outbreak in the same area on November 27 and 28.

There were no major outbreaks in the first half of 2005, which is rather unusual.

This means that there is the possibility of a major outbreak occurring within four weeks.

There was a major outbreak covering the whole of Britain in 1865/66.