In some waterfront areas, driftwood is a major nuisance.
They are also a major nuisance at some airports, where their size makes them a significant birdstrike hazard.
Volvo surveys had found (among many other things) that women drivers considered caps to be a major nuisance.
Regularly switching back to a laptop or standard model would be a major nuisance.
And as a private citizen, believe me, you are looked on as a major nuisance.
I tripped over it constantly and it became a major nuisance.
Any debris in the plaster can become a major nuisance.
For the rest of the family, they're a major nuisance - horror stories that ruin every celebration.
The wind coming in off the sea kept the temperature down and prevented insects from becoming a major nuisance.
Minor family, major nuisance, but also a born bootlicker, and those could be useful.