But for all the successes, there are major limitations as well.

These diseases also cause major limitations in daily living for almost 1 out of 10 Americans or about 25 million people.

"These companies will need to compromise their strategies - and we're talking major limitations."

The major limitation will be the test's cost, he said, and the problems of counseling to explain what the test results mean.

This is no major limitation because bridges are usually left or destroyed in place.

A major limitation here is that updating would be in the hands of the user.

However, until the mid-20th century there were a series of major limitations.

Old Smoke was a miracle but he had major limitations.

The following is a broad discussion of the major limitations.

These film cameras had a major limitation in the form of 4-minute load times.