Three major epidemics have occurred in the past hundred years, in 1896 - 1906, 1920, and 1970.
He attracted a large following among Indians who had already suffered major epidemics and dispossession of their lands.
Distress was exacerbated by outbreaks of plague, with major epidemics in the periods 1584-8 and 1597-1609.
In major epidemics, the attack rate range is 100 to 800 people per 100,000.
An increase in genetic similarity of agricultural plants and animals means an increased risk of food loss from major epidemics.
The region has also avoided any major epidemics so far.
In addition, major epidemics occur every 8-12 years.
So far, diarrhea, skin diseases and eye infections have been reported, but no major epidemics.
In Morocco, which has suffered major epidemics of the disease, it has had a devastating effect.
Two major epidemics are occurring in China, the United Nations said.