One major downside, however, is that it doesn't conduct heat well.

Forced paid subscription is a major downside for Microsoft service.

The major downside to the new scheme hasn't been eliminated; it has only been diminished a little.

Jefe, if there is a major downside to this proposal venture, I do not see it.

The only major downside to the design is that it required more power to run.

Finally the one major downside is the controlled substance restrictions.

The high level of flexibility that it offers over your tasks is very appealing, but there are some major downsides.

Repulsive systems have a major downside as well.

The review did, however, find the ending to be weak and one of its major downsides.

Comment: However, two major downsides, which need special handling, may exist: