This provided the first major clue as to what it was that was wrong.

Tweety usually stays with Granny and is responsible for some major clues.

If the scientists are right, then a major clue about how cancer develops in children has been found.

The painting ends up being one of the major clues in solving the murder.

The next major clue to the economy's performance is Friday's employment report for September.

Detectives hope that one major clue to the identity of the babies mother is the distinctive garment in which the body was wrapped.

To set the communications net searching would have been to provide any hunters with a major clue.

The link between them had been the major clue.

The lack of a protective suit here should have been a major clue.

I dropped some pretty major clues in there.