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Lumenal proteins can be predicted computationally based on their targeting signals.
Additional low-abundance lumenal proteins can be predicted through computational methods.
Disruption of isolated thylakoids, for example by mechanical shearing, releases the lumenal fraction.
Thylakoids contain many integral and peripheral membrane proteins, as well as lumenal proteins.
The catalytic domain of 11-cis-retinol dehydrogenase is restricted to the lumenal compartment, suggesting its origin from compartmentalized process.
Treatment must also include a lumenal amoebicide to prevent reinvasion of tissues by amoebae still in the intestines (see Amoebiasis).
The water-splitting reaction occurs on the lumenal side of the thylakoid membrane and is driven by the light energy captured by the photosystems.
Activating arteriole smooth muscle can decrease the lumenal diameter 1/3 of resting so it drastically alters blood flow and resistance.
Activation of aortic smooth muscle doesn't significantly alter the lumenal diameter but serves to increase the viscoelasticity of the vascular wall.
This is best supported by the presence of an oxygen-sensitive potassium channel coupled to an oxygen sensory protein in the lumenal membrane in the rabbit.
Late endosomes, also known as MVBs, are mainly spherical, lack tubules, and contain many close-packed lumenal vesicles.
The active site of OST is located about 4 nm from the lumenal face of the ER membrane.
The lumen of the thylakoids is also the site of water oxidation by the oxygen evolving complex associated with the lumenal side of photosystem II.
This heteromerization of the p24 proteins has been shown to require a coiled-coil stretch at the extreme carboxyl terminus of their lumenal regions [ 10].
It consists of a large (50 kDa) N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic tail.
The endosomal sorting complexes required for transport (ESCRTs) recognise this ubiquitin and sort the protein into the forming lumenal vesicles.
Late in pregnancy, uterine serpin protein can be found in the lumenal epithelium as well, perhaps as glandular epithelial cells move to the uterine lumen.
Synthesis of galactosylceramide, and glucosylceramide occurs on the lumenal surface of the endoplasmic reticulum, and on the cytosolic side of the early Golgi membranes respectively.
The activated EGFRs stimulate their own ubiquitination, and this directs them to lumenal vesicles (see below) and so they are not recycled to the plasma membrane.
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER).
Amoebic dysentery can be treated with metronidazole but must be followed up with a second lumenal drug to eliminate amoebae from the intestine (see Amoebiasis for more detail).
Also, in some circumstances, late endosomes/MVBs fuse with the plasma membrane instead of with lysosomes, releasing the lumenal vesicles, now called exosomes, into the extracellular medium.
The contractile function of vascular smooth muscle also regulates the lumenal diameter of the small arteries-arterioles called resistance vessels, thereby contributing significantly to setting the level of blood pressure.
An increase in the media to lumenal diameter ratio has been observed in hypertensive arterioles (arteriolosclerosis) as the vascular wall thickens and/or lumenal diameter decreases.
Water oxidation is catalyzed by a manganese-containing enzyme complex known as the oxygen evolving complex (OEC) or water-splitting complex found associated with the lumenal side of thylakoid membranes.