It opened in 1966 at the Globe Theatre and ran for six and half years until 1973 - over a thousand performances - to become the longest-running comedy in the history of the West End.
Tonight Fox will show the 300th episode, and next season "The Simpsons" will surpass "Ozzie and Harriet" as the longest-running comedy in TV history.
The show's eighth series (broadcast late 2012) makes it the longest-running comedy in Channel 4 history.
The original version by the Reduced Shakespeare Company was first performed at the Edinburgh Fringe Festival in 1987 and is London's longest-running comedy.
His biggest success, Run for Your Wife, lasted nine years in London's West End and is its longest-running comedy.
"The Simpsons," television's longest-running comedy, will offer its take on the controversy next season on Fox.
Although it rarely cracked the Nielsen Top 20, the series has been one of television's longest-running live-action comedies (second on Fox only to "Married With Children").
It was the ultimate last call for the longest-running comedy on television.
"The King of Queens," the longest-running live-action comedy currently on television, is the opposite of an acquired taste.