Now, other drugs have come into use for hot flashes, but not much is known about their effectiveness or long-term safety.

There have been no rigorous medical studies to provide answers to fundamental questions about long-term safety.

The study found no side effects, but the long-term safety is unknown, she said.

These studies should address the serious issues: long-term safety and efficacy.

But questions about the long-term safety of the drug remain unanswered.

Those who object to the science argue that more research is needed on long-term safety.

But concerns over long-term safety have prompted new attention from regulators.

But the study urged more research to determine long-term safety.

Not much is known about the long-term safety of red yeast rice.

Further studies to determine the long-term safety of this product are ongoing.