Engineered by Joseph Locke, the Sheffield, Ashton-under-Lyne and Manchester Railway linking Manchester and Sheffield opened in 1845.

The Sheffield, Ashton-under-Lyne and Manchester Railway Company was founded in 1836 with the purpose of building a line linking Manchester and Sheffield.

The station is on the Sheffield-Lincoln line (Route SY4) and is also served by the infrequent Saturdays only service linking Sheffield and Cleethorpes via Brigg.

Woodhouse is also served by the irregular Saturday only service linking Sheffield and Cleethorpes via Brigg.

Numerous calls have been made to extend the motorway to link Sheffield and Manchester, the fifth and sixth most populous cities in the United Kingdom.

The Woodhead Pass (A628) is an alternative road route to the Snake Pass linking Manchester and Sheffield.

In 1897 The Lancashire, Derbyshire and East Coast Railway opened its line through Tuxford, linking Sheffield and Chesterfield with Lincoln.

The brickworks, along with the local pottery, was served by a branch of the South Yorkshire Railway from 1850, this becoming a through line linking Sheffield and Doncaster from 1864.

The Hope Valley Line is a trans-Pennine railway line in England linking Sheffield with Manchester.

The Woodhead Line was a railway line linking Sheffield, Penistone and Manchester in the north of England.