Hinduism maintains that anything which causes the mind to lose balance with itself leads to misery.
The change never took hold, and led only to misery and confusion.
That had led to the war, and to untold misery before that, for several generations.
But nice European story eventually led to misery as club went to bankruptcy and was dissolved.
Failure to do so actively leads to misery for the individual and for his family.
If some of your decisions would have led to misery or disaster, think again about why you thought they were right rather than wrong.
At the end of the story, Marge's explanation is that revenge can lead to misery and sadness.
Expecting perfection, then, is bound to lead to misery.
Perhaps this can also apply to all the other places in the world where intolerance leads to misery and death.
Over the course of the book, his wealth leads to misery.