Jackson led Louisville in sacks with nine and tackles for a loss with 16.
Spencer and Jerome Harmon led Louisville with 14 points each.
Two of them allowed Osborne to lead Louisville to a 2-0 victory.
Marques Maybin had 25 points to lead Louisville (2-2) despite being limited to nine minutes in the second half because of foul trouble.
Smith led Louisville, which won its eighth straight game, with 22 points.
Smith led Louisville's balanced scoring with 24 points, followed by Brewer with 19.
Garcia leads Louisville in scoring, assists, steals and blocked shots.
Kenny Payne led Louisville with 19 points, which included 5-for-5 shooting from the field in the first half.
Francisco Garcia, the sophomore forward from the Bronx, led Louisville with 20 points despite playing on a bad ankle.
Dean led Louisville with 13 points.