Although many functions of Pax6 are known, the molecular mechanisms of these functions remain largely unresolved.

Despite two separate hearings before different judges, the legal questions surrounding the marriages remained largely unresolved.

But Republicans and Democrats alike acknowledged they were leaving the country's immigration problems largely unresolved.

As the title of the film suggests, these dilemmas remain largely unresolved.

The plot remained largely unresolved as low viewing figures meant a second series was not commissioned.

At this point, these issues remain largely unresolved.

The original handling problems were largely unresolved.

Tax issues remain largely unresolved, and the question of who owns virtual goods - the players or the game company - is open to debate.

The issue was left largely unresolved, and the reduction in fishing activity brought about by the First World War effectively ended the dispute.

The big questions are largely unresolved.