Pentylenetetrazol produces a reliable discriminative stimulus which is largely mediated by the GABA receptor.

For instance, in the dog kidney although 80 per cent of the receptors are of subtype vaso-constriction is largely mediated by receptors (,).

Before computers, the workspace was largely mediated by genres such as the paper memo,or the company newsletter.

Visually presented object recognition is largely mediated by a hierarchical occipitotemporal pathway.

The first is that reflexes are largely mediated by the lower parts of the brain, and the second is that they are less rigid than one might think.

Patients whose heart rate is largely mediated by the sympathetic nervous system (e.g. patients with congestive heart failure or myocardial infarct) should avoid nadolol as it inhibits sympathetic function.

The biological effects of the ω-3 and ω-6 fatty acids are largely mediated by their mutual interactions, see Essential fatty acid interactions for detail.

Degradation in soil appears to be largely biologically mediated, and produces a number of metabolites.

The biological effects of the omega 6 fatty acids are largely mediated by their conversion to omega-6 eicosanoids that bind to diverse receptors found in every tissue of the body.

The binding is largely mediated by electrostatic interactions between the DNA and the "thumb" and "palm" domains of the metaphorically hand-shaped DNA polymerase molecule.