Cardiogenic shock is a largely irreversible condition and as such is more often fatal than not.

This is particularly important in retroviral infections since viral integration into the host genome occurs quickly after entry and reverse transcription and is largely irreversible.

Primary and secondary stage lesions may heal completely, but the destructive changes of tertiary yaws are largely irreversible.

Traditionally, the loss of muscle mass had seemed an inevitable and largely irreversible consequence of aging.

Because sterilization is a largely irreversible procedure, post-sterilization regret is a major psychological effect.

Generally, stunting occurs before the age of 2, with largely irreversible effects.

Smil warns that while air pollution is amenable to dramatic high-tech fixes, land degradation is largely irreversible, except in some instances and at extremely high costs.

This has resulted in a substantial and largely irreversible loss in the diversity of life on Earth.

While the effects of aging may be largely irreversible, the effects of bed rest can almost always be overcome.

Lead is a toxin that is particularly harmful to the developing brain and nervous system, causing serious and largely irreversible damage in children at relatively low levels of exposure.