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Defects of the kinin-kallikrein system in diseases are not generally recognized.
It is a component of the kinin-kallikrein system.
Kininogen-1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system.
Kinin-kallikrein system.
There are hypotheses that many of the ACE-inhibitors' beneficial effects are due to their influence on the kinin-kallikrein system.
ACE cleaves a number of other peptides, and in this capacity is an important regulator of the kinin-kallikrein system, as such blocking ACE can lead to side effects.
The kinin-kallikrein system makes bradykinin by proteolytic cleavage of its kininogen precursor, high-molecular-weight kininogen (HMWK or HK), by the enzyme kallikrein.
The kinin-kallikrein system or simply kinin system is a poorly understood system, not much research has been carried out on this, of blood proteins that play a role in inflammation, blood pressure control, coagulation and pain.