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HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system.
Beraldo, W.T. and Andrade, S.P.: Discovery of bradykinin and the kallikrein-kinin system.
Journal of the Renin-Angiotensin-Aldosterone System also publishes research on other peptides, such as vasopressin, the natriuretic peptides and the kallikrein-kinin system.
ACE exists predominantly as an ectoenzyme of vascular endothelial cells and plays a key part in the renin-angiotensin and kallikrein-kinin systems by activating angiotensin I into angiotensin II and inactivating bradykinin.