The following may increase the risk of kidney late effects:

At higher exposures there may be kidney effects, respiratory failure and death.

Therefore, elderly people may be at a greater risk for kidney effects or shortness of breath while using this drug.

"The main thing we're concerned about with high levels of uranium is the kidney effects."

Older adults may be more sensitive to the effects of this drug, especially kidney effects.

The authors of the study identify the kidney effects as the most prominent chemically-related effect.

Statistical comparisons were not conducted for the increased severity of the kidney effect.

Other effects noted in humans include cardiac arrhythmia, liver damage, and possible kidney effects.

Older adults may be at greater risk for stomach/intestinal bleeding and kidney effects while using this drug.

Therefore, kidney effects are considered supportive but are not used as a primary basis for the RfD.