Once a species lives in two different areas, the geographical isolation makes breeding between the groups reduce or stop.

In instances of domestic violence, this isolation may make it difficult for women to find the help they need.

The isolation of the park, however, makes it a difficult day trip.

Its isolation and complete quiet make it a perfect place for thinking.

His isolation from normal society and the company of women had made him a little peculiar, to say the least.

The isolation of the region made it difficult to fight the epidemic.

In other words, there could be no legal objection to its routine use, given that the isolation didn't make everyone crazy.

Polarization and isolation of groups will make this more difficult.

The reserve's small size and isolation from other natural areas also make species extinction a much greater risk.

Its relative isolation from the nearby forests makes it easy to identify.