The irony of the name he had given was not lost on me.
The irony of the situation was not lost on him, however.
The irony of the question was not lost on him.
The irony of the situation was not lost on her.
The irony of it all is not lost on him.
The irony of this is certainly not lost on him.
The irony of his words was not lost on her.
The irony of it all was not lost on her.
The irony was not lost on him even after so many years.
I have to say that the irony of this is not lost on me.