This process is called signal transduction: The binding initiates a chemical change on the intracellular side of the membrane.

Drugs which block sodium channels by blocking from the intracellular side of the channel include:

Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane in eukaryotic cells.

It is generally accepted that capsaicin acts on and binds to the TRPV1 receptor from the intracellular side prior to activation.

They form trimers with two transmembrane helices per subunit and both the C and N termini on the intracellular side.

Both the N-terminus and C-terminus lie on the intracellular side of the membrane.

Once dopamine binds, the protein undergoes a conformational change, which allows both sodium and dopamine to unbind on the intracellular side of the membrane.

Perfusion of the intracellular side can be performed.

The P-loop enters the membrane of the pore from the extracellular side and exits to the intracellular side.

Phenylalkylamines are thought to access calcium channels from the intracellular side, although the evidence is somewhat mixed.