Blocking CD47 function has been shown to inhibit migration and metastasis in a variety of tumor models.
S1P at this physiological concentration stimulates migration and invasion of epithelial ovarian cancer cells but inhibits migration of normal ovarian surface epithelial cells.
Diosmin reduces the expression of endothelial adhesion molecules (ICAM1, VCAM1), and inhibits the adhesion, migration, and activation of leukocytes at the capillary level.
The significant loss of wetlands and the blocking of passageways to those wetlands that remain has inhibited salmon spawning and migration in the James Bay area.
Integrins are one of the structures that link cells together, and the complex formation may inhibit detachment and migration of the cancer cells.
TSP-1 is an antiangiogenic, inhibiting the proliferation and migration of endothelial cells by interactions with CD36 expressed on their surface of these cells.
Through this mechanisam, apoptosis is inhibited, angiogenesis, migration, adhesion, and invasion occur.
An in vitro study in a human glioblastoma cell line reported that curcumin may inhibit tumor cell proliferation, migration and invasion, and that these effects may be mediated through interference with a signaling pathway.
Inhibition of miRNA-26a accelerates SMC differentiation, and also promotes apoptosis, while inhibiting proliferation and migration.
Apart from infections, there are some other diseases where impaired chemotaxis is the primary etiological factor, as in Chediak-Higashi syndrome where giant intracellular vesicles inhibit normal migration of cells.