A 'sedative' is a substance that induces sedation by reducing irritability or excitement.

In Phase II trials, the compound was significantly superior to placebo without inducing sedation.

It is also used for its sedative properties as a premed before anesthesia or to induce sedation after anesthesia.

It is also used as a premedication for inducing sedation, anxiolysis or amnesia before certain medical procedures (e.g., endoscopy).

Mostly this can be mediated by its strong affinity to the μ-opioid receptor, inducing euphoria, sedation, and other prototypical morphinian effects .

A sedative or tranquilizer (or tranquilliser, see American and British English spelling differences) is a substance that induces sedation by reducing irritability or excitement.

Induce rapid sedation with IV midazolam when catastrophic hemorrhage occurs.

The drug is used for treatment of acute seizures, moderate to severe insomnia, and for inducing sedation and amnesia before medical procedures.

It has been commonly used to induce deep sedation, "twilight sleep" or general anesthesia for oral surgery and dentistry.

Likewise, administration of DOPA to laboratory animals was shown to reverse reserpine induced sedation; a finding reproduced in humans.