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This demyelination arises idiopathically following infections or vaccination, or due to multiple sclerosis.
It may occur idiopathically (idiopathic proctitis).
A spontaneous CSF leak, as opposed to traumatically caused CSF leaks, arises idiopathically.
Acoustic neuromas may occur idiopathically (meaning the cause is unknown), or in some cases occur as part of von Recklinghausen neurofibromatosis, in which case the neuroma may take on one of two forms.
There is also possibility of anti-cardiac antibodies created idiopathically, or due to concurrent cross-reactivity of the antibodies produced against viral antigens, however the latter assumption is not fool-proof or completely reliable due to conflicting studies.