We were interested in identifying non-HLA loci for celiac disease.
Neither have genome-wide association studies brought a consistent focus - each has identified new loci.
Around one-third of people with psoriasis report a family history of the disease, and researchers have identified genetic loci associated with the condition.
Researchers have identified specific loci in chromosomes 16 and 22, which have been reported to have a genotype-phenotype correlation.
For a few highly heritable traits, some studies have identified loci associated with variance in that trait in some individuals.
For example, research groups have identified loci that are associated with schizophrenia (Harrison and Owen, 2003) in subsets of patients with that diagnosis.
Rather than seeking to identify individual loci significantly associated with a trait, genomics uses all marker data as predictors of performance and consequently delivers more accurate predictions.
SubAim 1.1 will identify loci contributing to the occurrence and type of epilepsy.
SubAim 1.2 will identify loci associated with pharmacoresponse to AEDs.
Thus, there are at least 32 identified genetic loci required for viability or fertility in the centric heterochromatin.