Carnosine can increase the Hayflick limit in human fibroblasts, and also appears to reduce the rate of telomere shortening.
He helped to develop methods for the production of human fibroblast (beta) interferon that enabled its clinical utilization and molecular characterization.
Nemosis is a process of cell activation and death in human fibroblasts.
Later he and his team generated iPS cells from human adult fibroblasts, again as the first group to do so.
Telomere length predicts replicative capacity of human fibroblasts.
There is a lack of substantial telomerase activity in some cell types such as primary human fibroblasts, which become senescent after about 30-50 population doublings.
In 2009, Freed et al. demonstrated successful reprogramming of human fibroblasts to iPS cells.
Researchers have recently used this technique to express reprogramming proteins in primary human fibroblasts.
Kinetin delays onset of aging characteristics in human fibroblasts.
The researchers used cultured human fibroblasts obtained from cervical skin that was either intact or exposed to radioactive treatment (5000 rad).