"But there is a potential huge payoff environmentally, economically and for public health if we succeed."

Spending what it takes to make it work has a huge payoff.

"As a teacher, I'd like to think it's going to have a huge payoff," he said.

Never invest in anything that promises huge payoffs with no risk.

Getting in early can mean a huge payoff down the road.

The huge payoffs, like the California jackpot this week, build up over several weeks.

"For us it's a huge payoff - to get these kids, to give them their break."

First, the odds of any given research project resulting in a huge payoff is extremely small.

This offers huge potential payoffs for American policy, and both sides should work hard to make it a reality.

And I believe, absolutely, that we are about to get a huge payoff for taking a very small chance.