Trimethaphan causes a histamine release which further lowers blood pressure.

Mechanisms other than allergen-antibody interactions are known to cause histamine release from mast cells.

Alcohol is known to have close interactions with histamine release.

Fentanyl has the benefit of less histamine release and thus fewer side effects.

Antibiotics like polymyxin are also found to stimulate histamine release.

Consequently, it is frequently used when an allergic reaction requires fast, effective reversal of a massive histamine release.

When this occurs, the permeability of vessels near the area of histamine release is increased.

Symptoms may include abdominal pain, diarrhea, or any symptoms of histamine release.

Conformational or structural explanations for histamine release are not clear.

Unlike some of its predecessors alfaxalone is not associated with histamine release and anaphylaxis.