Both their formation and operation may be heavily constrained by the state through its managers.
Yet only 6 of the 42 African nations with endemic malaria - whose decisions are heavily constrained by outsiders - have changed drugs.
The Durban Street Circuit was heavily constrained by the location of the streets and the locations of the grandstands with seating for only 22,000 constructed for the 2006 event.
This activity was, however, heavily constrained by politics, as each target needed to be approved by all nineteen member states.
Because of their limited range, their potential use was heavily constrained (they could not, for example, threaten Moscow with an immediate strike).
Nearly all the agricultural civilizations have been heavily constrained by their environments.
The spacecraft's design had been heavily constrained by the need to receive signals across the solar system from that era's comparatively low-powered transmitters.
Before the revolution, I met the leaders of the opposition parties which existed, albeit with their activities heavily constrained.
As a result, characters were at the same time wildly unbalanced in terms of attributes and heavily constrained in terms of skills.
A Spanish military unit was called for help, but Spanish troops, heavily constrained by restrictive rules of engagement, were allowed only to provide cover from distance for the convoy's retreat.