OPD type II includes these abnormalities as well as growth deficiency and abnormalities of the brain and is frequently not compatible with life.

Some patients had persuaded their doctors to prescribe the drug when the F.D.A. approved it in late 2006 for children with growth deficiencies.

All affected individuals have prenatal-onset growth deficiency followed by postnatal growth retardation and hypotonia with muscle underdevelopment.

Individuals with AOS may have mild growth deficiency, with height in the lower normal percentiles.

Generally, a trained physician will determine growth deficiency and FAS facial features.

After the initial period of growth deficiency, affected individuals experience gradual improvement in bone growth that leads to normal physical development by early childhood.

The symptoms of this disorder may include abnormalities of the skull and facial features, growth deficiencies, underdeveloped nails of the fingers and toes, and/or mild developmental delays.

Normally, there is growth deficiency resulting in short stature.

The Human Growth Foundation is a nonprofit group that works with people with growth deficiencies.

In 1994 it published a study that concluded that 20,000 children needed human growth hormone because of their growth deficiencies.