It is her greatest sadness that she had no children.

But after the enjoyment of sensual pleasure is past, the greatest sadness follows.

The greatest sadness is losing the possibility of supporting young artists'

The greatest sadness was the children who felt unwanted.

But the greatest sadness is not to try and fail but to fail to try.

His source of greatest sadness was the death of his son John in India.

The Queen, with the greatest sadness, has asked for the following announcement to be made immediately.

Failure can be sad, but the greatest sadness is not to try and fail, but to fail to try.

"The greatest sadness of this city is that people have been cut off from one another."

Thus death causes the greatest sadness.