A heart must be a great annoyance to one.

Not knowing was a great annoyance to a man at his level of government.

Their presence in this otherwise perfect landscape was a great annoyance.

To his great annoyance, he had to be down in Mexico that day.

Perhaps they had never lost track of one before and this was sure to be a great annoyance.

Then, to his great annoyance, the room started to spin around him, and he knew nothing more.

Technology had been stolen similarly from Jupiter, to our great annoyance.

He died a silent death, a matter of great annoyance to those who sent him to it.

To her great annoyance a bag of sugar broke open spilling over the back seat.

In the nineteenth century the revolt against domestic service was just beginning, to the great annoyance of everyone with over £500 a year.