Homer purchases a severed monkey's hand that will grant four wishes, despite the vendor's warning that the wisher will meet with grave misfortune.

And so you will appreciate, Your Worships, that my client has suffered from a series of grave misfortunes.

Sterility, therefore, was widely regarded as a grave misfortune.

Any family possessing it would suffer grave misfortune.

A grave misfortune for men who could have given the best fruits of their intellect for many more years.

A family is afflicted with a series of grave misfortunes.

Are mama and my sisters truly in sanctuary - or could it be that some grave misfortune has overtaken them also?

It's a most grave misfortune.

International public opinion is watching and assessing how the European family handles the grave misfortune suffered by one of its members.

We just have the grave misfortune to live in the region where the Quintara, and the others, went first.