But even at this early stage his lack of hands was a grave disadvantage.

All these groups will suffer grave social disadvantages.

Some of them are potent ganglion blocking agents and were introduced into clinical medicine, but they had grave disadvantages.

As regards their political careers, they have the grave disadvantage of being patricians.

One thing was certain . . . they were at a grave disadvantage trying to fight in the darkness.

There was a grave disadvantage to any stalling tactics.

A Nigerian politician who has no access to, or is not reported by, any news medium is at a grave disadvantage.

That would put American institutions at a grave competitive disadvantage.

Stoddard also shows inheritance as a grave disadvantage to women.

But for all of the appeal of that message, at the outset of the race he faces grave political disadvantages.