It went against his very nature to give in to fear.
I'll go against my better nature this once and chance it.
It seemed to go against her nature to be so controlled.
And it was wrong to expect him to go against his nature.
I would not have you do anything that goes against your nature.
"It just goes against his nature to say something simple."
He knew that went against her very nature and beliefs.
However, it went against her nature to back down once the die was cast.
In order to succeed you have to go against your nature.
Defeat went against his nature, but attack was out of the question.